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Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo

Journal article
Authors X. T. Wang
Y. Chen
X. T. Zuo
N. Q. Ding
H. J. Zeng
X. Zou
Xiaodong Han
Published in Food and Chemical Toxicology
Volume 60
Pages 309-317
ISSN 0278-6915
Publication year 2013
Published at Institute of Biomedicine
Pages 309-317
Language en
Links dx.doi.org/10.1016/j.fct.2013.07.03...
Keywords Microcystin-LR, Apoptosis, Testicular cells, Mouse, PROTEIN PHOSPHATASES, DNA-DAMAGE, LAKE TAIHU, P53, CYANOBACTERIA, EXPRESSION, TOXINS, VITRO, BAX, HEPATOTOXICITY
Subject categories Clinical Medicine

Abstract

Microcystin-LR (MC-LR) can induce apoptosis of a wide range of tissue cells including testicular cells. The purpose of the study was to find out whether the expression and phosphorylation of p53, Bcl-2 protein family proteins, Cyt c, and caspases were involved in the induction of testicular cell apoptosis by MC-LR in mice. Results showed that following exposure to MC-LR, expression of Bax, caspase 3 and caspase 8 was up-regulated. Significant increases in the phosphorylation of both p53 and Bcl-2 were identified after the administration of MC-LR. The administration of MC-LR also resulted in significant increases of c-myc, c-jun, and c-fos. In conclusion, p53, Bcl-2, Bax, Caspase 3 and Caspase 8 are involved in the regulation of MC-LR-induced apoptosis of testicular cells. The overexpression of c-myc, c-jun and c-fos suggests that MC-LR may have carcinogenic potential for testes. (C) 2013 Elsevier Ltd. All rights reserved.

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