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Increasing participation in cervical cancer screening: Offering a HPV self-test to long-term non-attendees as part of RACOMIP, a Swedish randomized controlled trial.

Journal article
Authors Gudrun Broberg
Dorte Gyrd-Hansen
Junmei Miao Jonasson
Mare-Liis Ryd
Mikael Holtenman
Ian Milsom
Björn Strander
Published in International Journal of Cancer
Volume 134
Issue 9
Pages 2223-2230
ISSN 0020-7136
Publication year 2014
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 2223-2230
Language en
Links dx.doi.org/10.1002/ijc.28545
Keywords mass screening, papanicolaou smear, ervical intraepithelial neoplasia, HPV, non-attendance
Subject categories Cancer and Oncology, Obstetrics and women's diseases

Abstract

RACOMIP is a population-based, randomized trial of the effectiveness and cost-effectiveness of different interventions aimed at increasing participation in a well-run cervical cancer screening program in western Sweden. In this article, we report results from one intervention, offering non-attendees a high-risk human papillomavirus (HPV) self-test. Comparison was made with standard screening invitation routine or standard routine plus a telephone call. Women (8,800), aged 30-62, were randomly selected among women without a registered Pap smear in the two latest screening rounds. These women were randomized 1:5:5 to one of three arms: 800 were offered a high-risk HPV self-test, 4,000 were randomized to a telephone call (reported previously) and 4,000 constituted a control group (standard screening invitation routine). Results were based on intention to treat analysis and cost-effectiveness was calculated as marginal cost per cancer case prevented. The endpoint was the frequency of testing. The total response rate in the self-testing arm was 24.5%, significantly higher than in the telephone arm (18%, RR 1.36, 95% CI 1.19-1.57) and the control group (10.6%, RR 2.33, 95% CI 2.00-2.71). All nine women who tested positive for high-risk HPV attended for a cervical smear and colposcopy. From the health-care sector perspective, the intervention will most likely lead to no additional cost. Offering a self-test for HPV as an alternative to Pap smears increases participation among long-term non-attendees. Offering various screening options can be a successful method for increasing participation in this group.

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