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The Discriminating Properties of an Optoelectronic Movement Analysis Method in Patients With Parkinsonism

Journal article
Authors Theresa Zackrisson
Filip Bergquist
M. Eklund
Björn Holmberg
Thorleif Thorlin
Published in Journal of Motor Behavior
Volume 45
Issue 5
Pages 415-422
ISSN 0022-2895
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 415-422
Language en
Links dx.doi.org/10.1080/00222895.2013.81...
Keywords movement disorder, neurodegenerative disorder, objective quantification, optoelectronic movement, MULTIPLE SYSTEM ATROPHY, PROGRESSIVE SUPRANUCLEAR PALSY, RICHARDSON-OLSZEWSKI-SYNDROME, DIFFERENTIAL-DIAGNOSIS, CLINICAL-DIAGNOSIS, CSF-NEUROFILAMENT, RATING-SCALES, DISEASE, TESTS, PERFORMANCE
Subject categories Clinical Medicine

Abstract

Several partly overlapping diseases have Parkinsonism as a symptom and tools that may differentiate between these disorders would be helpful. The authors evaluated the discriminating properties of the objective automated posturo-locomotor-manual (PLM) L-DOPA test in regard to health, and the movement disorders Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). A PLM test-retest procedure was performed in healthy controls (n = 37) and results were compared with PLM L-DOPA tests performed by 132 patients with Parkinsonism in intermediate to advanced stages (56 PD, 53 MSA, 23 PSP). The movement time (MT) for the standardized movement and its different components was measured. The discriminating abilities of individual, or combinations of, test variables were determined by forward stepwise multiple logistic regression and evaluated with receiver-operating characteristic (ROC) analysis. Each PLM variable separated healthy persons from patients with Parkinsonism before administration of L-DOPA (area under the curve (AUC) = 0.94-0.99, p < .001 for any separate variable). A combination of (MToff - MTon)/MToff and MTon had the highest ability to separate patients with PD from patients with atypical Parkinsonism (area under the curve = 0.91, p < .001). The PLM test discriminates between healthy controls and patients with Parkinsonism, and between patients with Parkinson's disease and patients with atypical Parkinsonism.

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