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Shift of Enterovirus species among children in Cameroon - Identification of a new enterovirus, EV-A119

Journal article
Authors James Ayukekbong
Jean-Claude Kabayiza
Magnus Lindh
T. Nkuo-Akenji
F. Tah
Tomas Bergström
Helene Norder
Published in Journal of Clinical Virology
Volume 58
Issue 1
Pages 227-232
ISSN 1386-6532
Publication year 2013
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 227-232
Language en
Links dx.doi.org/10.1016/j.jcv.2013.07.00...
Keywords Enterovirus, Cameroon, Phylogenetic analysis, Species, ACUTE-FLACCID-PARALYSIS, LIKELIHOOD METHODS, RECOMBINATION, POLIOVIRUSES, PARSIMONY, EVOLUTION, INFECTION, SEQUENCES, VIRUSES
Subject categories Clinical Medicine

Abstract

Background: Infections caused by human enteroviruses (EVs) are often asymptomatic or mild, although they may cause more severe illnesses as meningitis and acute flaccid paralysis. EVs have globally posed a threat to children, and outbreaks of aseptic meningitis and hand, foot and mouth disease are frequently reported. Objective: To identify EV strains circulating among healthy children in a small community in Limbe, Cameroon two years apart. Study design: Species and EV types were obtained by partial 5'UTR-VP4 and VP1 sequencing of RNA from stool samples collected in October 2009 and September 2011 from 150 children in Cameroon. Results: In all, 74 children (49%) were infected with 28 different types of EV. There were 29 (54%) infected children in 2009, and 45 (47%) in 2011. There was a significant difference between detected species of EV, with 15 (47%) children infected with EV-A in 2009, and 22 (71%) with EV-B in 2011 (p = 0.0001). In 2009, one child was infected by a divergent EV, which was most similar to EV-A90. Based on the complete VP1 sequence, it was shown to be a new EV designated EV-A119. Conclusion: The current study shows a high heterogeneity of circulating EV types among children in Limbe, Cameroon, and a previously not described shift in predominating EV species. (C) 2013 Elsevier B. V. All rights reserved.

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