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The glial marker YKL-40 is decreased in synucleinopathies.

Journal article
Authors Bob Olsson
Radu Constantinescu
Björn Holmberg
Niels Andreasen
Kaj Blennow
Henrik Zetterberg
Published in Movement disorders : official journal of the Movement Disorder Society
Volume 28
Issue 14
Pages 1882–1885
ISSN 1531-8257
Publication year 2013
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 1882–1885
Language en
Subject categories Neurochemistry, Clinical Medicine


Microglia are resident immunosurveillant cells in the central nervous system, and astrocytes are important for blood flow, plasticity, and neurotransmitter regulation. The aim of this study was to investigate whether astrocyte and microglial activation, estimated through markers in cerebrospinal fluid and serum, differed between synucleinopathies, tauopathies, and controls.

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