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Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Journal article
Authors J. Song
Z. Lokmic
T. Lammermann
Julia Rolf
C. Wu
X. L. Zhang
R. Hallmann
M. J. Hannocks
N. Horn
M. A. Ruegg
A. Sonnenberg
E. Georges-Labouesse
T. H. Winkler
J. F. Kearney
Susanna Cardell
L. Sorokin
Published in Proceedings of the National Academy of Sciences of the United States of America
Volume 110
Issue 31
Pages E2915-E2924
ISSN 0027-8424
Publication year 2013
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages E2915-E2924
Language en
Links dx.doi.org/10.1073/pnas.1218131110
Keywords B-cell development, immunology, SPLENIC WHITE PULP, LAMININ ALPHA-5 CHAIN, MARGINAL-ZONE, T-CELL, IN-VIVO, MICE, MOLECULES, INTEGRINS, SYSTEM, GROWTH
Subject categories Clinical Medicine

Abstract

We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin alpha 5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin alpha 5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin alpha 6 beta 1-mediated interaction of NF B cells with laminin alpha 5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.

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