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Cord blood neutrophils display a galectin-3 responsive phenotype accentuated by vaginal delivery.

Journal article
Authors Martina Sundqvist
Veronica Osla
Bo Jacobsson
Anna Rudin
Karin Sävman
Anna Karlsson
Published in BMC pediatrics
Volume 13
Pages artikel nr 128
ISSN 1471-2431
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Clinical Sciences, Department of Pediatrics
Pages artikel nr 128
Language en
Links dx.doi.org/10.1186/1471-2431-13-128
Subject categories Immunobiology, Rheumatology and Autoimmunity, Pediatrics

Abstract

Term neonates are at increased risk of infections due to undeveloped immune mechanisms, and proper neutrophil function is important for perinatal immune defence. Galectin-3, an endogenous β-galactoside-binding lectin, is emerging as an inflammatory mediator and we have previously shown that primed/activated, but not resting, adult neutrophils respond to this lectin by production of reactive oxygen species (ROS). We investigated if galectin-3 is of importance in perinatal immune defence, focusing on plasma levels and neutrophil responsiveness.

Page Manager: Webmaster|Last update: 9/11/2012
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