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Memory B Cells in Mouse Models

Journal article
Authors B. Bergmann
Ola Grimsholm
Brynja Kristin Thorarinsdottir
Weicheng Ren
Pernilla Jirholt
Inger Gjertsson
Inga-Lill Mårtensson
Published in Scandinavian Journal of Immunology
Volume 78
Issue 2
Pages 149-156
ISSN 0300-9475
Publication year 2013
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 149-156
Language en
Links dx.doi.org/10.1111/sji.12073
Keywords helper t-cells, tertiary lymphoid structures, class switch, recombination, germinal center formation, primary immune-response, plasma-cells, somatic hypermutation, antibody-responses, clonal, selection, autoimmune-disease, Animals, Autoimmune Diseases, pathology, B-Lymphocyte Subsets, immunology, pathology, Disease Models, Animal, Gene Expression, immunology, Germinal Center, immunology, pathology, Humans, Immunity, Cellular, Immunoglobulin Isotypes, biosynthesis, Immunologic Memory, Mice, Receptors, Antigen, B-Cell, genetics, immunology, T-Lymphocytes, immunology, pathology
Subject categories Medical cell biology, Clinical immunology

Abstract

One of the principles behind vaccination, as shown by Edward Jenner in 1796, and host protection is immunological memory, and one of the cells central to this is the antigen-experienced memory B cell that responds rapidly upon re-exposure to the initiating antigen. Classically, memory B cells have been defined as progenies of germinal centre (GC) B cells expressing isotype-switched and substantially mutated B cell receptors (BCRs), that is, membrane-bound antibodies. However, it has become apparent over the last decade that this is not the only pathway to B cell memory. Here, we will discuss memory B cells in mice, as defined by (1) cell surface markers; (2) multiple layers; (3) formation in a T cell-dependent and either GC-dependent or GC-independent manner; (4) formation in a T cell-independent fashion. Lastly, we will touch upon memory B cells in; (5) mouse models of autoimmune diseases.

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