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Prevotella jejuni sp. nov., isolated from the small intestine of a child with celiac disease.

Journal article
Authors Maria E Hedberg
Anne Israelsson
Edward R.B. Moore
Liselott Svensson-Stadler
Sun Nyunt Wai
Grzegorz Pietz
Olof Sandström
Olle Hernell
Marie-Louise Hammarström
Sten Hammarström
Published in International journal of systematic and evolutionary microbiology
Volume 63
Issue 11
Pages 4218-4223
ISSN 1466-5034
Publication year 2013
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 4218-4223
Language en
Links dx.doi.org/10.1099/ijs.0.052647-0
Subject categories Clinical Medicine

Abstract

Five obligately anaerobic, Gram-negative, saccharolytic and proteolytic, non-spore-forming bacilli (CD3:27, CD3:28T, CD3:33, CD3:32 and CD3:34) are described. All five strains were isolated from the small intestine of a female child with celiac disease. The cells of the five strains were observed to be short rods or coccoid cells with longer filamentous forms seen sporadically. The organisms produced acetic acid and succinic acid as major metabolic end products. Phylogenetic analysis, based on comparative 16S rRNA gene sequence analysis revealed close relationships between CD3:27, CD3:28T and CD3:33 on one hand, between CD3:32 and P. histicola CCUG 55407T and between CD3:34 and P. melaninogenica CCUG 4944BT on the other. The strains CD3:27, CD3:28T and CD3:33 were clearly different from any other species within the genus Prevotella and most closely related to but distinct from P. melaninogenica. Based on 16S rRNA gene, RNA polymerase β-subunit gene and 60-kDa chaperonin protein subunit gene sequencing, phenotypic, chemical and biochemical properties strains CD3:27, CD3:28T and CD3:33 have been determined to represent a novel species within the genus Prevotella, named Prevotella jejuni sp. nov. Strain CD3:28T (CCUG 60371T = DSM 26989T) is the type strain of the proposed new species. All five strains were able to form homologous aggregates, in which tube-like structures were connecting individual bacteria cells. The five strains were able to bind to human intestinal carcinoma cell lines at 37 °C.

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