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Disease mechanisms in MS: Phases of disease improvement unrelated to relapses.

Review article
Authors Oluf Andersen
Published in Nature reviews. Neurology
Volume 8
Issue 11
Pages 596-8
ISSN 1759-4766
Publication year 2012
Published at Institute of Neuroscience and Physiology
Pages 596-8
Language en
Subject categories Clinical Medicine


Natural history of multiple sclerosis includes phases of relapse, remission and insidious progression. New data show that sustained improvements in disease, defined by reductions in EDSS scores, occur independent of relapses almost half as frequently as disease worsening. This finding might facilitate research into the biological processes involved in disease improvement.

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