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Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.

Journal article
Authors Ghazaleh Samoudi
Hans Nissbrandt
Mayank B Dutia
Filip Bergquist
Published in PloS one
Volume 7
Issue 1
Pages e29308
ISSN 1932-6203
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages e29308
Language en
Links dx.doi.org/10.1371/journal.pone.002...
https://gup.ub.gu.se/file/110641
Keywords Acoustic Stimulation, methods, Animals, Behavior, Animal, physiology, Disease Models, Animal, Female, Locomotion, physiology, Male, Models, Biological, Noise, Parkinsonian Disorders, metabolism, physiopathology, therapy, Rats, Rats, Sprague-Dawley, Substantia Nigra, metabolism, Vestibule, Labyrinth, physiology, gamma-Aminobutyric Acid, metabolism
Subject categories Neurobiology

Abstract

The vestibular system is connected to spinal, cerebellar and cerebral motor control structures and can be selectively activated with external electrodes. The resulting sensation of disturbed balance can be avoided by using stochastic stimulation patterns. Adding noise to the nervous system sometimes improves function. Small clinical trials suggest that stochastic vestibular stimulation (SVS) may improve symptoms in Parkinson's disease. We have investigated this claim and possible mechanisms using the 6-hydroxydopamine (6-OHDA) hemilesion model of Parkinson's disease.

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