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TGF-β1 promotes transition of mesothelial cells into fibroblast phenotype in response to peritoneal injury in a cell culture model.

Journal article
Authors Peter Falk
Eva Angenete
Maria Bergström
Marie-Louise Ivarsson
Published in International journal of surgery (London, England)
Volume 11
Issue 9
Pages 977–982
ISSN 1743-9159
Publication year 2013
Published at Institute of Clinical Sciences, Department of Surgery
Pages 977–982
Language en
Links dx.doi.org/10.1016/j.ijsu.2013.06.0...
Keywords Adhesion formation, Mesothelial cells, Peritoneum, Transforming growth factor, Proliferation and experimental model
Subject categories Surgery

Abstract

Peritoneal adhesions are a clinical problem. A key to the understanding of peritoneal adhesions is to study the healing of mesothelial cells within the peritoneal cavity following surgery. Transforming growth factor beta (TGF-βs) affects this healing process. The aim of this study was to investigate the effects of different concentrations of TGF-β1 on the healing rate and healing properties of mesothelial cells.

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