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Genetic variation in the receptor for advanced glycation end-products (RAGE) gene and ischaemic stroke

Journal article
Authors Sandra Olsson
Katarina Jood
Published in European Journal of Neurology
Volume 20
Issue 6
Pages 991-993
ISSN 1351-5101
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 991-993
Language en
Keywords AGER, genetics, single nucleotide polymorphism, small-vessel disease, TOAST, subtype, disease
Subject categories Clinical Medicine


Background and purpose The multi-ligand receptor for advanced glycation end-products (RAGE, alias AGER) is suggested to contribute to the pathogenesis of vascular disease, but its potential role in stroke is unclear. The aim of this study was to investigate whether genetic variation in RAGE gene is associated with ischaemic stroke (IS). Methods The Sahlgrenska Academy Study on Ischaemic Stroke comprises 844 Caucasian patients with first ever (n = 732) and recurrent (n = 112) IS, and 668 Caucasian controls. Three tagSNPs were selected to capture genetic variation in the RAGE gene. IS subtypes were determined using TOAST criteria. Results One SNP, rs1035798, showed significant association with the subtype of small-vessel disease (SVD) after correction for multiple testing (OR 1.56, 95% CI 1.16–2.09), adjusted P-value < 0.05). This association was independent of hypertension, diabetes and smoking. None of the SNPs was associated with overall IS. Conclusion In this sample of patients with IS, genetic variation in RAGE is associated with the IS subtype SVD, but not overall IS.

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