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Peak picking as a pre-processing technique for imaging time of flight secondary ion mass spectrometry

Journal article
Authors Jimmy D. Moore
Alex Henderson
John S. Fletcher
Nicholas P. Lockyer
John C. Vickerman
Published in Surface and Interface Analysis
Volume 45
Issue 1
Pages 461–465
ISSN 0142-2421
Publication year 2013
Published at Department of Chemistry and Molecular Biology
Pages 461–465
Language en
Links onlinelibrary.wiley.com/doi/10.1002...
Subject categories Analytical Chemistry

Abstract

High surface sensitivity and lateral resolution imaging make time-of-flight secondary ion mass spectrometry (ToF-SIMS) a unique and powerful tool for biological analysis. However, with the leaps forward made in the capabilities of the ToF-SIMS instrumentation, the data being recorded from these instruments has dramatically increased. Unfortunately, with these large, often complex, datasets, a bottleneck appears in their processing and interpretation. Here, an application of peak picking is described and applied to ToF-SIMS images allowing for large compression of data, noise removal and improved contrast, while retaining a high percentage of the original signal. Peak picking is performed to locate peaks within ToF-SIMS data. By using this information, signal arising from the same distribution can be summed and overlapping signals separated. As a result, the data size and complexity can be dramatically reduced. This method also acts as an effective noise filter, discarding unwanted noise from the data set. Peak picking and separation are evaluated against the conventional methods of mass binning and manually selecting regions of a peak to image on a model data set.

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