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Glycoprotein 130 promotes human blastocyst development in vitro

Journal article
Authors F. Hambiliki
Jörg Hanrieder
J. Bergquist
J. Hreinsson
A. Stavreus-Evers
K. Wanggren
Published in Fertility and Sterility
Volume 99
Issue 6
Pages 1592-U444
ISSN 0015-0282
Publication year 2013
Published at
Pages 1592-U444
Language en
Keywords Blastocyst, LIF, gp130, MALDI-TOF MS, ICMS
Subject categories Obstetrics and women's diseases


Objective: To investigate the efficacy of leukemia inhibitory factor (LIF) and/or glycoprotein 130 Design: Laboratory study. Setting: University hospital-based IVF clinic. Patient(s): A total of 164 frozen embryos that survived thawing were cultured in media supplemented Intervention(s): Morphological development was evaluated by light microscopy. Protein expression Main Outcome Measure(s): Embryo development and protein content. Result(s): Addition of gp130 to culture media improved blastocyst formation (73% vs. 43%). Addition of Conclusion(s): Glycoprotein 130, but not LIF, seems to be beneficial for preimplantation embryo

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