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Children and adolescents with follicular lymphoma have an excellent prognosis with either limited chemotherapy or with a "watch and wait" strategy after complete resection.

Journal article
Authors Andishe Attarbaschi
Auke Beishuizen
Georg Mann
Angelo Rosolen
Tetsuya Mori
Anne Uyttebroeck
Felix Niggli
Monika Csoka
Zdenka Krenova
Karin Mellgren
Edita Kabickova
Alan Ks Chiang
Alfred Reiter
Denise Williams
Birgit Burkhardt
Published in Annals of hematology
Volume 92
Issue 11
Pages 1537-1541
ISSN 1432-0584
Publication year 2013
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 1537-1541
Language en
Keywords Follicular lymphoma, Complete resection, “Watch and wait”, Outcome
Subject categories Pediatrics


Data on clinical features and outcome in pediatric follicular lymphoma (pFL) are scarce. The aim of this retrospective study including 13 EICNHL and/or i-BFM study group members was to assess clinical characteristics and course in a series of 63 pFL patients. pFL was found to be associated with male gender (3:1), older age (72 % ≥10 years old), low serum LDH levels (<500 U/l in 75 %), grade 3 histology (in 88 %), and limited disease (87 % stage I/II disease), mostly involving the peripheral lymph nodes. Forty-four out of sixty-three patients received any polychemotherapy and 1/63 rituximab only, while 17/63 underwent a "watch and wait" strategy. Of 36 stage I patients, 30 had complete resections. Only one patient relapsed; 2-year event-free survival and overall survival were 94 ± 5 and 100 %, respectively, after a median follow-up of 2.2 years. Conclusively, treatment outcome in pFL seems to be excellent with risk-adapted chemotherapy or after complete resection and an observational strategy only.

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