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Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid.

Journal article
Authors Lars-Eric Tisell
Håkan Ahlman
Bo Wängberg
Lars Kölby
M Fjälling
Eva Forssell-Aronsson
Johan Mölne
Ola Nilsson
Published in British journal of cancer
Volume 79
Issue 9-10
Pages 1579-82
ISSN 0007-0920
Publication year 1999
Published at Institute of Selected Clinical Sciences, Department of Radiation Physics
Institute of Laboratory Medicine, Dept of Pathology
Institute of Surgical Sciences, Department of Surgery
Pages 1579-82
Language en
Links dx.doi.org/10.1038/sj.bjc.6690251
Keywords Adenoma, Oxyphilic, metabolism, radionuclide imaging, Adult, Aged, Aged, 80 and over, Blotting, Northern, Female, Humans, Indium Radioisotopes, metabolism, Male, Middle Aged, Neoplasm Proteins, blood, metabolism, Octreotide, analogs & derivatives, diagnostic use, Pentetic Acid, analogs & derivatives, RNA, Messenger, metabolism, Receptors, Somatostatin, blood, metabolism, Thyroid Neoplasms, metabolism, radionuclide imaging
Subject categories Cancer and Oncology

Abstract

Ten consecutive patients with Hürthle cell lesions of the thyroid (nodule/adenoma/carcinoma) were studied by (111)In-DTPA-D-Phe1-octreotide scintigraphy. Octreotide scintigraphy localized the primary Hürthle cell tumour in eight patients as distinct areas of increased uptake of radionuclide. Two patients with Hürthle cell carcinoma, previously thyroidectomized, had their metastases visualized by octreotide scintigraphy. Northern analyses showed expression of multiple somatostain receptor subtypes. Visualization of the Hürthle cell tumour may be due to a higher expression of somatostatin receptors in the lesions than in surrounding normal thyroid tissue. The tissue/blood (111)In concentration ratios for tumour samples from five patients showed clearly higher values than observed for normal connective tissue, muscle or lymph nodes. A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease.

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