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Efficacy of the Screening Algorithm WINROP in a Korean Population of Preterm Infants

Journal article
Authors J. H. Choi
Chatarina Löfqvist
Ann Hellström
H. Heo
Published in Jama Ophthalmology
Volume 131
Issue 1
Pages 62-66
ISSN 2168-6165
Publication year 2013
Published at Institute of Neuroscience and Physiology
Pages 62-66
Language en
Keywords longitudinal postnatal weight, premature-infants, intravitreal, bevacizumab, risk-factors, retinopathy, prediction, gain
Subject categories Ophthalmology


Objective To investigate the efficacy of WINROP (, an algorithm based on serial measurements of neonatal body weight to predict proliferative retinopathy of prematurity (ROP), in a Korean population of preterm infants. Methods The records of preterm infants with gestational age less than 32 weeks who were admitted to the neonatal intensive care unit at Chonnam National University Hospital, Gwangju, South Korea, from October 2006 to November 2010 were reviewed. The body weight of infants was measured weekly and entered into a computer-based surveillance system, WINROP, and the outcome was analyzed. Results A total of 314 preterm infants participated in the study. The mean gestational age was 29 weeks (range, 25-32 weeks). The mean body weight was 1263 g (range, 590-2260 g). For 166 of 314 infants (52.9%), a high-risk alarm was noted. In the high-risk alarm group, 36 infants developed type 1 ROP, according to the Early Treatment for Retinopathy of Prematurity criteria, and they were treated for ROP. The remaining 148 infants (47.1%) had a low-risk alarm. In the low-risk alarm group, 3 infants with bronchopulmonary dysplasia and intraventricular hemorrhage, a risk factor for ROP, and 1 infant without any risk factors for ROP developed type 1 ROP and were treated. Conclusions In a Korean population, the WINROP algorithm had a sensitivity of 90% for identifying infants with type 1 ROP. Although some limitations are present, adjustment to the WINROP algorithm for a specific population may improve the efficacy of predicting proliferative ROP and reduce the frequency of retinal examinations.

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