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Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ.

Journal article
Authors Björg Kristjansdottir
Kristina Levan
Karolina Partheen
Elisabet Carlsohn
Karin Sundfeldt
Published in Clinical proteomics
Volume 10
Issue 1
Pages 4
ISSN 1542-6416
Publication year 2013
Published at Institute of Clinical Sciences, Department of Oncology
Institute of Biomedicine
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 4
Language en
Keywords Ovarian adenocarcinoma, Ovarian cyst fluid, Tumor biomarker, Mass spectrometry, iTRAQ
Subject categories Obstetrics, Gynecology and Reproductive Medicine


Epithelial-derived ovarian adenocarcinoma (EOC) is the most deadly gynecologic tumor, and the principle cause of the poor survival rate is diagnosis at a late stage. Screening and diagnostic biomarkers with acceptable specificity and sensitivity are lacking. Ovarian cyst fluid should harbor early ovarian cancer biomarkers because of its closeness to the tumor. We investigated ovarian cyst fluid as a source for discovering biomarkers for use in the diagnosis of EOC.

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