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Ghrelin mediates anticipation to a palatable meal in rats.

Journal article
Authors Myrte Merkestein
Maike A D Brans
Mieneke C M Luijendijk
Johannes W de Jong
Emil Egecioglu
Suzanne L. Dickson
Roger A. H. Adan
Published in Obesity (Silver Spring, Md.)
Volume 20
Issue 5
Pages 963-71
ISSN 1930-739X
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 963-71
Language en
Keywords Animals, Anticipation, Psychological, drug effects, physiology, Appetite, drug effects, Feeding Behavior, Ghrelin, blood, metabolism, pharmacology, Male, Motivation, Motor Activity, drug effects, Rats, Rats, Wistar, Receptors, Ghrelin, antagonists & inhibitors
Subject categories Endocrinology and Diabetes


Food anticipatory activity (FAA) is displayed in rats when access to food is restricted to a specific time frame of their circadian phase, a behavior thought to reflect both hunger and the motivation to eat. Rats also display FAA in a feeding schedule with ad libitum access to normal chow, but limited availability of a palatable meal, which is thought to involve mainly motivational aspects. The orexigenic hormone ghrelin has been implicated in FAA in rodents with restricted access to chow. Because ghrelin plays an important role not only in the control of food intake, but also in reward, we sought to determine the role of ghrelin in anticipation to a palatable meal. Plasma ghrelin levels of non-restricted rats that anticipated chocolate correlated positively with FAA and were increased compared with chow-fed control rats. Furthermore, centrally injected ghrelin increased, whereas an antagonist of the ghrelin receptor decreased, the anticipation to chocolate. Therefore, we hypothesize that central ghrelin signaling is able to mediate the motivational drive to eat.

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