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Image-based 3D modeling study of the influence of vessel density and blood hemoglobin concentration on tumor oxygenation and response to irradiation.

Journal article
Authors Jakob Heydorn Lagerlöf
Jon Kindblom
Eliane Cortez
Kristian Pietras
Peter Bernhardt
Published in Medical physics
Volume 40
Issue 2
Pages 024101
ISSN 0094-2405
Publication year 2013
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 024101
Language en
Links dx.doi.org/10.1118/1.4773886
Keywords biochemistry, biological effects of radiation, blood, blood vessels, cellular biophysics, diffusion, Green's function methods, medical disorders, medical image processing, oxygen, radiation therapy, tumours, tumor control probability, dosimetry, modeling, hypoxia, radiotherapy
Subject categories Cancer and Oncology, Radiological physics

Abstract

Hypoxia is one of the most important factors influencing clinical outcome after radiotherapy. Improved knowledge of factors affecting the levels and distribution of oxygen within a tumor is needed. The authors constructed a theoretical 3D model based on histological images to analyze the influence of vessel density and hemoglobin (Hb) concentration on the response to irradiation.

Page Manager: Webmaster|Last update: 9/11/2012
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