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Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?

Journal article
Authors Patrick Jern
Lars Westberg
A. Johansson
Lina Jonsson
J. Corander
N. K. Sandnabba
P. Santtila
Published in Bju International
Volume 110
Issue 11C
Pages E1173-E1180
ISSN 1464-4096
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages E1173-E1180
Language en
Links dx.doi.org/10.1111/j.1464-410X.2012...
Keywords premature ejaculation, oxytocin receptor, vasopressin receptor, gene, polymorphism, population-based sample, premature ejaculation, delayed ejaculation, transporter gene, sexual desire, latency time, associations, rat, identification, localization
Subject categories Pharmacology and Toxicology

Abstract

OBJECTIVES To investigate associations between single nucleotide polymorphisms (SNPs) linked to the oxytocin, To investigate these associations in a large, population-based sample. PATIENTS AND METHODS In all, 1517 male twins and non-twin brothers of twins aged 18-45 years (mean = 26.43; SD = 4.87) A Bayesian linear mixed-effects model, which appropriately controls for between subjects dependence, We corrected for multiple testing using a linkage disequilibrium correlation measure. RESULTS We found a heterozygote effect on one SNP in the oxytocin receptor gene (rs75775), so that individuals Several SNPs in the arginine vasopressin receptor genes had rare or very rare genotypes. This study CONCLUSIONS Our results regarding the oxytocin receptor polymorphisms support previous studies that indicate a Oxytocin receptor genes are, for example, unlikely suitable targets for pharmacogenetic intervention Rare variants in arginine vasopressin receptor genes may have significant effects on premature

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