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In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1.

Journal article
Authors Kostas Bougas
Ryo Jimbo
Stefan Vandeweghe
Nick Tovar
Marta Baldassarri
Ali Alenezi
Malvin Janal
Paulo G Coelho
Ann Wennerberg
Published in Clinical implant dentistry and related research
Volume 16
Issue 5
Pages 728-735
ISSN 1708-8208
Publication year 2014
Published at
Pages 728-735
Language en
Subject categories Biomaterials


PURPOSE: The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo. MATERIALS AND METHODS: Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1. RESULTS: After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. CONCLUSIONS: Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.

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