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Poor correlation between spectrophotometric intracutaneous analysis and histopathology in melanoma and nonmelanoma lesions.

Journal article
Authors Karin Terstappen
Mart Suurküla
Håkan Hallberg
Marica B Ericson
Ann-Marie Wennberg
Published in Journal of Biomedical Optics
Volume 18
Issue 6
Pages 61223
ISSN 1083-3668
Publication year 2013
Published at Institute of Clinical Sciences, Department of Dermatology and Venereology
Institute of Biomedicine, Department of Pathology
Department of Physics (GU)
Pages 61223
Language en
Keywords malignant melanoma; imaging; colorimetric analysis; histopathology; skin cancer diagnostics
Subject categories Dermatology and Venereal Diseases


ABSTRACT. Spectrophotometric intracutaneous analysis (SIAscopy) is an imaging technique developed for diagnostics of pigmented skin lesions. By image analysis, the displayed images indicate the potential distribution and position of melanin, blood, and collagen within the lesion. A topographic comparison was performed between SIAscopic findings and histopathology. In total, 60 patients with suspicious pigmented skin lesions were included. The lesions were SIAscopically imaged and documented before excision and histopathological preparation. Topographical comparisons between SIAscopy findings and histopathology were made. A sensitivity and specificity of 24% and 84%, respectively, were obtained for invasive melanomas. The positive and negative predicted values were 58% and 54%, respectively. The features indicating dermal melanin, blood displacement and collagen holes did only show "no" to "slight" agreement with histopathology, i.e., κ≤0.21. It was concluded that (i) SIAscopy-based diagnosis has low diagnostic accuracy for melanoma, (ii) single SIAscopic features do not provide reliable diagnostic information relating to the lesions internal structure on histopathology examination and (iii) SIAscopy cannot be used as a guide for localizing the maximum tumor thickness when performing the histopathological examination. The importance of validating new optical tools for tumor diagnostics with histopathological findings was demonstrated.

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