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In search of a consensus terminology in the field of platelet concentrates for surgical use: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes.

Journal article
Authors David M Dohan Ehrenfest
Tomasz Bielecki
Allan Mishra
Piero Borzini
Francesco Inchingolo
Gilberto Sammartino
Lars Rasmusson
Peter A Evert
Published in Current pharmaceutical biotechnology
Volume 13
Issue 7
Pages 1131-7
ISSN 1873-4316
Publication year 2012
Published at
Pages 1131-7
Language en
Keywords Biocompatible Materials, metabolism, therapeutic use, Blood Platelets, physiology, Fibrin Tissue Adhesive, metabolism, Humans, Leukocytes, physiology, Platelet-Derived Growth Factor, metabolism, Platelet-Rich Plasma, physiology, Polymerization
Subject categories Biomaterials

Abstract

In the field of platelet concentrates for surgical use, most products are termed Platelet-Rich Plasma (PRP). Unfortunately, this term is very general and incomplete, leading to many confusions in the scientific database. In this article, a panel of experts discusses this issue and proposes an accurate and simple terminology system for platelet concentrates for surgical use. Four main categories of products can be easily defined, depending on their leukocyte content and fibrin architecture: Pure Platelet-Rich Plasma (P-PRP), such as cell separator PRP, Vivostat PRF or Anitua's PRGF; Leukocyteand Platelet-Rich Plasma (L-PRP), such as Curasan, Regen, Plateltex, SmartPReP, PCCS, Magellan, Angel or GPS PRP; Pure Plaletet-Rich Fibrin (P-PRF), such as Fibrinet; and Leukocyte- and Platelet-Rich Fibrin (L-PRF), such as Choukroun's PRF. P-PRP and L-PRP refer to the unactivated liquid form of these products, their activated versions being respectively named P-PRP gels and L-PRP gels. The purpose of this search for a terminology consensus is to plead for a more serious characterization of these products. Researchers have to be aware of the complex nature of these living biomaterials, in order to avoid misunderstandings and erroneous conclusions. Understanding the biomaterials or believing in the magic of growth factors ? From this choice depends the future of the field.

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