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The anticaries effect of a food extract (shiitake) in a short-term clinical study.

Journal article
Authors Peter Lingström
Egija Zaura
Haidar Hassan
Mark J Buijs
Pamie Hedelin
Jonathan Pratten
David Spratt
Maria Daglia
Aneta Karbowiak
Caterina Signoretto
Martijn Rosema
Fridus van der Weijden
Michael Wilson
Published in Journal of biomedicine & biotechnology
Volume 2012
Pages 217164
ISSN 1110-7251
Publication year 2012
Published at Institute of Odontology
Pages 217164
Language en
Keywords Adult, Amines, administration & dosage, Analysis of Variance, Bacteria, drug effects, Biofilms, drug effects, Cariostatic Agents, pharmacology, Dental Plaque, chemistry, drug therapy, microbiology, Double-Blind Method, Drug Combinations, Female, Humans, Hydrogen-Ion Concentration, Male, Mouthwashes, administration & dosage, chemistry, Questionnaires, Saliva, drug effects, microbiology, Shiitake Mushrooms, chemistry, Sucrose, Tin Fluorides, administration & dosage
Subject categories Cariology


The main objective was to investigate whether low-molecular-weight fraction of edible mushroom shiitake extract (Lentinus edodes) possesses caries-preventive properties. The study was designed as a double-blind, three-leg, cross-over, randomized, controlled clinical trial carried out on two series of volunteers at the University of Gothenburg, and the Academic Centre for Dentistry Amsterdam. Volunteers rinsed twice daily with a solution containing low-molecular-weight fraction of edible mushroom, placebo (negative control without active ingredients), or Meridol (positive control, AmF-SnF(2)) for two weeks, with a two-week washout period between each rinsing period. Changes in the acidogenicity of dental plaque before and after a sucrose challenge, shifts in microbial composition, and plaque scores were determined. Frequent rinses with shiitake reduced the metabolic activity of dental plaque. No reduction of plaque scores and no inhibition of the production of organic acids in plaque was found. Minor differences in microbial composition between test sessions were found. To conclude, the results indicate that shiitake extract has anticariogenic potential, but not to the same extent as the positive control.

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