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Evaluation of plant and fungal extracts for their potential antigingivitis and anticaries activity.

Journal article
Authors D A Spratt
M Daglia
A Papetti
M Stauder
D O'Donnell
L Ciric
A Tymon
B Repetto
C Signoretto
Y Houri-Haddad
M Feldman
D Steinberg
S Lawton
Peter Lingström
J Pratten
E Zaura
G Gazzani
C Pruzzo
M Wilson
Published in Journal of biomedicine & biotechnology
Volume 2012
Pages 510198
ISSN 1110-7251
Publication year 2012
Published at Institute of Odontology
Pages 510198
Language en
Keywords Anti-Bacterial Agents, pharmacology, Bacteria, drug effects, Beer, Biofilms, drug effects, Cariostatic Agents, pharmacology, Cell Adhesion, drug effects, Cell Aggregation, drug effects, Cell Line, Chicory, chemistry, Cytokines, metabolism, Fruit, chemistry, Gingivitis, microbiology, Humans, Hydroxyapatites, Plant Extracts, pharmacology, Shiitake Mushrooms, chemistry, Signal Transduction, Tea, chemistry
Subject categories Cariology


The link between diet and health has lead to the promotion of functional foods which can enhance health. In this study, the oral health benefits of a number of food homogenates and high molecular mass and low molecular mass fractions were investigated. A comprehensive range of assays were performed to assess the action of these foods on the development of gingivitis and caries using bacterial species associated with these diseases. Both antigingivitis and anticaries effects were investigated by assays examining the prevention of biofilm formation and coaggregation, disruption of preexisting biofilms, and the foods' antibacterial effects. Assays investigating interactions with gingival epithelial cells and cytokine production were carried out to assess the foods' anti- gingivitis properties. Anti-caries properties such as interactions with hydroxyapatite, disruption of signal transduction, and the inhibition of acid production were investigated. The mushroom and chicory homogenates and low molecular mass fractions show promise as anti-caries and anti-gingivitis agents, and further testing and clinical trials will need to be performed to evaluate their true effectiveness in humans.

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