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Early healing in alveolar sockets grafted with titanium granules. An experimental study in a dog model.

Journal article
Authors Thiago Arruda
Flávia Sukekava
André B de Souza
Lars Rasmusson
Maurício G Araújo
Published in Journal of biomedical materials research. Part A
Volume 101A
Issue 7
Pages 1971–1976
ISSN 1552-4965
Publication year 2013
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 1971–1976
Language en
Keywords titanium granules;grafting;bone formation;extraction socket;biomaterial
Subject categories Biomaterials


The aim of the present study was to evaluate the effect of the placement of titanium granules in fresh extraction sockets on early bone formation. The mesial roots of the third maxillary premolars of five adult beagle dogs were removed. On one side of the maxilla (Test group) the fresh extraction socket was grafted with titanium granules, while the contra-lateral socket was left non-grafted (Control group). After 1 month of healing, the dogs were euthanized and biopsies were obtained. The healing tissues were described, and histometric measurements were performed to obtain the percentage area occupied by connective tissue, new mineralized bone, bone marrow, and biomaterial particles. After 1 month of healing the findings from the histological examination revealed the titanium graft to be well incorporated into the provisional connective tissue or newly formed woven bone. The histometric measurements showed, however, that less mineralized bone was formed in the Test group than in the Control group. The present study suggests that the use of titanium granules in fresh extraction sockets was conducive to new bone formation. The graft of titanium granules seems, however, to delay the early phase of the healing process. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.

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