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Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA.

Journal article
Authors Yu Fang
L Larsson
P Bruhns
Zou Xiang
Published in Allergy
Volume 67
Issue 10
Pages 1233-40
ISSN 1398-9995
Publication year 2012
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Microbiology and Immunology
Pages 1233-40
Language en
Links dx.doi.org/10.1111/j.1398-9995.2012...
Keywords Apoptosis, mast cells, Fc receptors, allergy.
Subject categories Basic Medicine

Abstract

Mast cells are important effector cells in allergy. They usually have a long life span and resist cell death induction. Fcγ receptor- and IgG immune complex-mediated apoptosis has been demonstrated in B-lineage cells, but not in mast cells. The aim of the current study was to investigate whether mast cells could respond to apoptosis induction by IgG immune complex aggregation of Fcγ receptors. It is known that mouse mast cells express the low-affinity Fcγ receptors FcγRIIB and FcγRIIIA, which bind IgG especially in the form of antigen-IgG immune complexes.

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