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Perspectives on mucus properties and formation--lessons from the biochemical world.

Review article
Authors Daniel Ambort
Malin E V Johansson
Jenny K Gustafsson
Anna Ermund
Gunnar C. Hansson
Published in Cold Spring Harbor perspectives in medicine
Volume 2
Issue 11
Pages a014159
ISSN 2157-1422
Publication year 2012
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages a014159
Language en
Subject categories Cell and Molecular Biology


Our model of the MUC2 mucin shows a well-organized netlike gel that is cross-linked by six different covalent and noncovalent bonds. When the MUC2 mucin is packed in the mucin granule it is organized by an amino-terminal concatenated ring platform formed at high calcium and low pH. This packing allows an ordered release and a normal mucin expansion when calcium is removed and pH increased by bicarbonate. This process is defective in the absence of cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate transport. The expanded secreted mucin is suggested to be self-organizing by properties inherited in the MUC2 mucin and by proteolytic processes.

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