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Perspectives on mucus properties and formation--lessons from the biochemical world.

Review article
Authors Daniel Ambort
Malin E V Johansson
Jenny K Gustafsson
Anna Ermund
Gunnar C. Hansson
Published in Cold Spring Harbor perspectives in medicine
Volume 2
Issue 11
Pages a014159
ISSN 2157-1422
Publication year 2012
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages a014159
Language en
Links perspectivesinmedicine.cshlp.org/co...
Subject categories Cell and Molecular Biology

Abstract

Our model of the MUC2 mucin shows a well-organized netlike gel that is cross-linked by six different covalent and noncovalent bonds. When the MUC2 mucin is packed in the mucin granule it is organized by an amino-terminal concatenated ring platform formed at high calcium and low pH. This packing allows an ordered release and a normal mucin expansion when calcium is removed and pH increased by bicarbonate. This process is defective in the absence of cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate transport. The expanded secreted mucin is suggested to be self-organizing by properties inherited in the MUC2 mucin and by proteolytic processes.

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