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Gastric exocrine and endocrine cell morphology under prolonged acid inhibition therapy: results of a 5-year follow-up in the LOTUS trial.

Journal article
Authors R Fiocca
L Mastracci
S E Attwood
C Ell
J-P Galmiche
J Hatlebakk
A Bärthel
G Långström
T Lind
Lars Lundell
Cecilia Engström
Published in Alimentary pharmacology & therapeutics
Volume 36
Issue 10
Pages 959-71
ISSN 1365-2036
Publication year 2012
Published at
Pages 959-71
Language en
Subject categories Surgery


Sustained acid inhibition with PPI stimulates gastrin secretion, exerting a proliferative drive on enterochromaffin-like cells (ECL cells) of the oxyntic mucosa. It may also accelerate development of gastric gland atrophy in Helicobacter pylori-infected individuals.

Page Manager: Webmaster|Last update: 9/11/2012

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