To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Neurofilament protein in … - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Neurofilament protein in cerebrospinal fluid: a marker of white matter changes.

Journal article
Authors Magnus Sjögren
M Blomberg
Michael Jonsson
L O Wahlund
Åke Edman
Karin Lind
Lars Rosengren
Kaj Blennow
Anders Wallin
Published in Journal of neuroscience research
Volume 66
Issue 3
Pages 510-6
ISSN 0360-4012
Publication year 2001
Published at Institute of Clinical Neurosciences
Pages 510-6
Language en
Keywords Aged, Alzheimer Disease, cerebrospinal fluid, pathology, physiopathology, Amyloid beta-Peptides, cerebrospinal fluid, Apolipoprotein E4, Apolipoproteins E, genetics, Biological Markers, cerebrospinal fluid, Cerebral Cortex, metabolism, pathology, physiopathology, Dementia, Vascular, cerebrospinal fluid, pathology, physiopathology, Diagnosis, Differential, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, metabolism, pathology, Neurofilament Proteins, cerebrospinal fluid, Peptide Fragments, cerebrospinal fluid, Predictive Value of Tests, Serum Albumin, metabolism, Sex Factors, Wallerian Degeneration, cerebrospinal fluid, pathology, physiopathology, tau Proteins, cerebrospinal fluid
Subject categories Neuroscience, Neurochemistry


The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), nine patients with subcortical vascular dementia (SVD), and 20 normal controls were included in the study. The occurrence of WMC was evaluated by a neuroradiologist using the Blennow-Wallin scale. Thirty-seven subjects had no or only punctate WMC; 14 had moderate to severe WMC. Both diagnostic group and WMC, but not gender or apolipoproteinE E4 inheritance, contributed to the variance in the CSF levels of tau, NFL, and Abeta42. In patients with moderate to severe WMC, CSF NFL (P < 0.01), but not CSF tau or CSF Abeta42, was increased also after correction for age, gender, and degree of cognitive impairment. A comparison between patients and controls with any signs of WMC and those without such signs yielded a similar result: CSF NFL (P < 0.001) was increased in the group with signs of WMC. As in numerous previous studies, we found that CSF tau was increased in AD (P < 0.001) compared with controls. Furthermore, CSF NFL was increased in both AD and SVD compared with controls (P < 0.001 for both). Although diagnostic group seems to be a stronger predictor of the variance found in CSF NFL, a clear association between the presence of WMC and increased CSF NFL was found. Because NFL is located mainly in large myelinated axons, increased CSF NFL in individuals with WMC probably reflects axonal degeneration.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?