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Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor.

Journal article
Authors Onisha Patel
Daniel G Pellicci
Stephanie Gras
Maria L Sandoval-Romero
Adam P Uldrich
Thierry Mallevaey
Andrew J Clarke
Jérôme Le Nours
Alex Theodossis
Susanna Cardell
Laurent Gapin
Dale I Godfrey
Jamie Rossjohn
Published in Nature immunology
Volume 13
Issue 9
Pages 857-63
ISSN 1529-2916
Publication year 2012
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 857-63
Language en
Links dx.doi.org/10.1038/ni.2372
Keywords Animals, Antigens, CD1d, chemistry, immunology, Crystallization, Killer Cells, Natural, chemistry, immunology, Lymphocyte Activation, Mice, Polymerase Chain Reaction, Protein Structure, Quaternary, Receptors, Antigen, T-Cell, alpha-beta, chemistry, immunology, Sulfoglycosphingolipids, chemistry, immunology, Surface Plasmon Resonance, T-Lymphocyte Subsets, chemistry, immunology
Subject categories Basic Medicine

Abstract

Natural killer T cells (NKT cells) are divided into type I and type II subsets on the basis of differences in their T cell antigen receptor (TCR) repertoire and CD1d-antigen specificity. Although the mode by which type I NKT cell TCRs recognize CD1d-antigen has been established, how type II NKT cell TCRs engage CD1d-antigen is unknown. Here we provide a basis for how a type II NKT cell TCR, XV19, recognized CD1d-sulfatide. The XV19 TCR bound orthogonally above the A' pocket of CD1d, in contrast to the parallel docking of type I NKT cell TCRs over the F' pocket of CD1d. At the XV19 TCR-CD1d-sulfatide interface, the TCRα and TCRβ chains sat centrally on CD1d, where the malleable CDR3 loops dominated interactions with CD1d-sulfatide. Accordingly, we highlight the diverse mechanisms by which NKT cell TCRs can bind CD1d and account for the distinct antigen specificity of type II NKT cells.

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