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Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling.

Journal article
Authors Jessica Wahlgren
Tanya (De L.) Karlson
Pernilla Glader
Esbjörn Telemo
Hadi Valadi
Published in PLoS ONE
Volume 11
Issue 0049723
ISSN 1932-6203
Publication year 2012
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine
Language en
Links dx.doi.org/10.1371/journal.pone.004...
https://gup.ub.gu.se/file/92123
Keywords exosomes, IL2, T cells, CD3+, cytokines
Subject categories Medical cell biology

Abstract

It has previously been shown that nano-meter sized vesicles (30–100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools. Additionally, activated CD3+ T cells can secrete exosomes that have the ability to modulate different immunological responses. Here, we investigated what effects exosomes originating from activated CD3+ T cells have on resting CD3+ T cells by studying T cell proliferation, cytokine production and by performing T cell and exosome phenotype characterization. Human exosomes were generated in vitro following CD3+ T cell stimulation with anti-CD28, anti-CD3 and IL-2. Our results show that exosomes purified from stimulated CD3+ T cells together with IL-2 were able to generate proliferation in autologous resting CD3+ T cells. The CD3+ T cells stimulated with exosomes together with IL-2 had a higher proportion of CD8+ T cells and had a different cytokine profile compared to controls. These results indicate that activated CD3+ T cells communicate with resting autologous T cells via exosomes.

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