To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Activated Human T Cells S… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling.

Journal article
Authors Jessica Wahlgren
Tanya (De L.) Karlson
Pernilla Glader
Esbjörn Telemo
Hadi Valadi
Published in PLoS ONE
Volume 11
Issue 0049723
ISSN 1932-6203
Publication year 2012
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine
Language en
Keywords exosomes, IL2, T cells, CD3+, cytokines
Subject categories Medical cell biology


It has previously been shown that nano-meter sized vesicles (30–100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools. Additionally, activated CD3+ T cells can secrete exosomes that have the ability to modulate different immunological responses. Here, we investigated what effects exosomes originating from activated CD3+ T cells have on resting CD3+ T cells by studying T cell proliferation, cytokine production and by performing T cell and exosome phenotype characterization. Human exosomes were generated in vitro following CD3+ T cell stimulation with anti-CD28, anti-CD3 and IL-2. Our results show that exosomes purified from stimulated CD3+ T cells together with IL-2 were able to generate proliferation in autologous resting CD3+ T cells. The CD3+ T cells stimulated with exosomes together with IL-2 had a higher proportion of CD8+ T cells and had a different cytokine profile compared to controls. These results indicate that activated CD3+ T cells communicate with resting autologous T cells via exosomes.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?