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Cardiovascular Events After Bariatric Surgery in Obese Subjects With Type 2 Diabetes

Journal article
Authors Stefano Romeo
Cristina Maglio
Maria Antonella Burza
Carlo Pirazzi
Kajsa Sjöholm
Peter Jacobson
Per-Arne Svensson
M. Peltonen
Lars Sjöström
Lena M S Carlsson
Published in Diabetes Care
Volume 35
Issue 12
Pages 2613-2617
ISSN 0149-5992
Publication year 2012
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 2613-2617
Language en
Links dx.doi.org/10.2337/dc12-0193
Keywords disease risk, weight, mortality, adults, trends, sos
Subject categories Diabetology, Cardiovascular medicine

Abstract

OBJECTIVE-Obese individuals with type 2 diabetes have an increased risk of cardiovascular disease. The effect of bariatric surgery on cardiovascular events in obese individuals with type 2 diabetes remains to be determined. The Swedish Obese Subjects (SOS) study is a prospective, controlled intervention study that examines the effects of bariatric surgery on hard end points. The aim of the present study was to examine the effect of bariatric surgery on cardiovascular events in the SOS study participants with type 2 diabetes. RESEARCH DESIGN AND METHODS-All SOS study participants with type 2 diabetes at baseline were included in the analyses (n = 345 in the surgery group and n = 262 in the control group). Mean follow-up was 13.3 years (interquartile range 10.2-16.4) for all cardiovascular events. RESULTS-Bariatric surgery was associated with a reduced myocardial infarction incidence (38 events among the 345 subjects in the surgery group vs. 43 events among the 262 subjects in the control group; log-rank P = 0.017; adjusted hazard ratio [HR] 0.56 [95% CI 0.34-0.93]; P = 0.025). No effect of bariatric surgery was observed on stroke incidence (34 events among the 345 subjects in the surgery group vs. 24 events among the 262 subjects in the control group; log-rank P = 0.852; adjusted HR 0.73 [0.41-1.30]; P = 0.29). The effect of surgery in reducing myocardial infarction incidence was stronger in individuals with higher serum total cholesterol and triglycerides at baseline (interaction P value = 0.02 for both traits). BMI (interaction P value = 0.12) was not related to the surgery outcome. CONCLUSIONS-Bariatric surgery reduces the incidence of myocardial infarction in obese individuals with type 2 diabetes. Preoperative BMI should be integrated with metabolic parameters to maximize the benefits of bariatric surgery.

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