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Extreme Stability of Chitotriosidase in Cerebrospinal Fluid makes it a Suitable Marker for Microglial Activation in Clinical Trials

Journal article
Authors Bob Olsson
Clas Malmeström
H. Basun
P. Annas
Kina Höglund
L. Lannfelt
N. Andreasen
Henrik Zetterberg
Kaj Blennow
Published in Journal of Alzheimers Disease
Volume 32
Issue 2
Pages 273-276
ISSN 1387-2877
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 273-276
Language en
Links dx.doi.org/10.3233/jad-2012-120931
Keywords Alzheimer's disease, biomarker, cerebrospinal fluid, chitotriosidase, multiple sclerosis, stability, relapsing multiple-sclerosis, alzheimers-disease, natalizumab, integrin, csf
Subject categories Neurosciences

Abstract

Microglia is thought to be important in Alzheimer's disease. Therefore, our aim was to investigate the usefulness of the microglial marker chitotriosidase in clinical trials. Chitotriosidase was analyzed in cerebrospinal fluid from Alzheimer's disease patients on acetylcholine esterase inhibitors (AChEI) and in cerebrospinal fluid from multiple sclerosis patients before and after natalizumab treatment. Chitotriosidase activity was extremely stable during treatment with the non-inflammatory drug AChEI. However, the immunomodulatory treatment with natalizumab led to lower chitotriosidase activity. Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ.

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