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The Swedish Twin Registry: Establishment of a Biobank and Other Recent Developments.

Journal article
Authors Patrik K E Magnusson
Catarina Almqvist
Iffat Rahman
Andrea Ganna
Alexander Viktorin
Hasse Walum
Linda Halldner
Sebastian Lundström
Fredrik Ullén
Niklas Långström
Henrik Larsson
Anastasia Nyman
Clara Hellner Gumpert
Maria Råstam
Henrik Anckarsäter
Sven Cnattingius
Magnus Johannesson
Erik Ingelsson
Lars Klareskog
Ulf De Faire
Nancy L Pedersen
Paul Lichtenstein
Published in Twin research and human genetics : the official journal of the International Society for Twin Studies
Volume 16
Issue 1
Pages 317-29
ISSN 1832-4274
Publication year 2013
Published at Institute of Neuroscience and Physiology
Gillberg Neuropsychiatry Centre
Pages 317-29
Language en
Links dx.doi.org/10.1017/thg.2012.104
Keywords Register, Twin, Genetics
Subject categories Health Sciences, Child and adolescent psychiatry, Psychiatry

Abstract

The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.

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