To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

IgM-phosphorylcholine aut… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

IgM-phosphorylcholine autoantibodies and outcome in acute coronary syndromes.

Journal article
Authors Kenneth Caidahl
Marianne Hartford
Thomas Karlsson
Johan Herlitz
K Pettersson
U de Faire
J Frostegård
Published in International Journal of Cardiology
Volume 167
Issue 2
Pages 464-469
ISSN 0167-5273
Publication year 2012
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 464-469
Language en
Keywords Antibodies,Angina,Immune system,Myocardial infarction,Prognosis
Subject categories Cardiovascular medicine


Abstract BACKGROUND: Antibodies against proinflammatory phosphorylcholine (anti-PC) seem to be protective and reduce morbidity. We sought to determine whether low levels of immunoglobulin-M (IgM) autoantibodies against PC add prognostic information in acute coronary syndromes (ACS). METHODS: IgM anti-PC titers were measured in serum obtained within 24h of admission from 1185 ACS patients (median age 66years, 30% women). We evaluated major acute cardiovascular events (MACE) and all-cause mortality short- (6months), intermediate- (18months) and long- (72months) terms. RESULTS: Low anti-PC titers were associated with MACE and all-cause mortality at all follow-up times. After adjusting for clinical variables, plasma troponin-I, proBNP and CRP levels, associations remained at all times with MACE, short and intermediate terms also with all-cause mortality. With anti-PC titers below median, adjusted hazard ratios at 18months were for MACE 1.79 (95% confidence interval [CI]: 1.31 to 2.44; p=0.0002) and for all-cause mortality 2.28 (95% CI: 1.32 to 3.92; p=0.003). Anti-PC and plasma CRP were unrelated and added to risk prediction. CONCLUSIONS: Serum IgM anti-PC titers provide prognostic information above traditional risk factors in ACS. The ease of measurement and potential therapeutic perspective indicate that it may be a valuable novel biomarker in ACS.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?