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Controlling the cortical actin motor

Review article
Authors Julie Grantham
I. Lassing
R. Karlsson
Published in Protoplasma
Volume 249
Issue 4
Pages 1001-1015
ISSN 0033-183X
Publication year 2012
Published at Department of Chemistry and Molecular Biology
Pages 1001-1015
Language en
Links dx.doi.org/10.1007/s00709-012-0403-...
Keywords Cell motility, Actin dynamics, Actin-binding proteins, Actin folding, Molecular chaperone, CCT, eukaryotic cytosolic chaperonin, cross-linked profilin, fast-growing, end, arp2/3 complex, microfilament system, crystal-structure, beta-actin, f-actin, saccharomyces-cerevisiae, electron tomography
Subject categories Biochemistry

Abstract

Actin is the essential force-generating component of the microfilament system, which powers numerous motile processes in eukaryotic cells and undergoes dynamic remodeling in response to different internal and external signaling. The ability of actin to polymerize into asymmetric filaments is the inherent property behind the site-directed force-generating capacity that operates during various intracellular movements and in surface protrusions. Not surprisingly, a broad variety of signaling pathways and components are involved in controlling and coordinating the activities of the actin microfilament system in a myriad of different interactions. The characterization of these processes has stimulated cell biologists for decades and has, as a consequence, resulted in a huge body of data. The purpose here is to present a cellular perspective on recent advances in our understanding of the microfilament system with respect to actin polymerization, filament structure and specific folding requirements.

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