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Piperidine: effects on locomotor activity and brain monoamine turnover

Journal article
Authors Bernt Alm
Published in Psychopharmacology (Berl)
Volume 50
Issue 3
Pages 301-4
ISSN 00333158
Publication year 1976
Published at Department of pediatrics
Pages 301-4
Language en
Keywords Animals, Biogenic Amines/*metabolism, Brain/*metabolism, Dopamine/metabolism, Hydroxyindoleacetic Acid/metabolism, Male, Mice, Motor Activity/*drug effects, Norepinephrine/metabolism, Piperidines/*pharmacology, Reflex, Stretch/drug effects, Serotonin/metabolism
Subject categories Pharmacology and Toxicology, Pharmacology

Abstract

The effects of piperidine HCl (PHCl) on locomotor activity, flexor reflex activity and monoamine levels, turnover, and synthesis were studied. Results indicate a sedative action and an increased turnover of noradrenaline (NA), but no effects on 5-hydroxytryptamine (5-HT) or dopamine (DA). Data obtained from flexor reflex experiments suggest that this is not secondary to alpha-adrenergic receptor blockade. One explanation might be an increased impulse activity of NA neurons, but the exact mechanism remains to be elucidated.

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