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In vivo biomechanical stability of osseointegrating mesoporous TiO<sub>2</sub> implants

Journal article
Authors Johan Karlsson
Ryo Jimbo
Hoda Mashadi Fathali
Humberto Osvaldo Schwartz-Filho
Mariko Hayashi
Mats Halvarsson
Ann Wennerberg
Martin Andersson
Published in Acta Biomaterialia
Volume 8
Issue 12
Pages 4438-4446
ISSN 1742-7061
Publication year 2012
Published at
Pages 4438-4446
Language en
Keywords Osseointegration, Implant, Mesoporous TiO2, Nanotopography, Biomechanical stability
Subject categories Biomaterials

Abstract

Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.

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