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miRcode: a map of putative microRNA target sites in the long non-coding transcriptome

Journal article
Authors Ashwini Jeggari
D. S. Marks
Erik Larsson
Published in Bioinformatics
Volume 28
Issue 15
Pages 2062-2063
ISSN 1367-4803
Publication year 2012
Published at Institute of Biomedicine
Pages 2062-2063
Language en
Links dx.doi.org/10.1093/bioinformatics/b...
Keywords gene-expression, messenger-rnas, differentiation, chromatin, cancer
Subject categories Medical Genetics

Abstract

Although small non-coding RNAs, such as microRNAs, have well-established functions in the cell, long non-coding RNAs (lncRNAs) have only recently started to emerge as abundant regulators of cell physiology, and their functions may be diverse. A small number of studies describe interactions between small and lncRNAs, with lncRNAs acting either as inhibitory decoys or as regulatory targets of microRNAs, but such interactions are still poorly explored. To facilitate the study of microRNA-lncRNA interactions, we implemented miRcode: a comprehensive searchable map of putative microRNA target sites across the complete GENCODE annotated transcriptome, including 10 419 lncRNA genes in the current version.

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