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UniCarb-DB: a database resource for glycomic discovery

Journal article
Authors Catherine A Hayes
Niclas G. Karlsson
WB Struwe
F Lisacek
PM Rudd
NH Packer
MP Campbell
Published in BIOINFORMATICS
Volume 27
Issue 9
Pages 1343-1344
ISSN 1367-4803
Publication year 2011
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 1343-1344
Language en
Links dx.doi.org/10.1093/bioinformatics/b...
Subject categories Medical Biotechnology

Abstract

Glycosylation is one of the most important post-translational modifications of proteins, known to be involved in pathogen recognition, the innate immune response and protection of epithelial membranes. However, when compared to the tools and databases available for the processing of high-throughput proteomic data, the glycomic domain is severely lacking. While tools to assist the analysis of MS and HPLC are continuously improving there are few resources available to support LC-MS/MS techniques for glycan structure profiling. Here, we present a platform for presenting oligosaccharide structures and fragment data characterised by LC-MS/ MS strategies. The database is annotated with high-quality data sets and is designed to extend and reinforce those standards and ontologies developed by existing glycomics databases

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