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Replication and Recombination of Herpes Simplex Virus DNA

Review article
Authors Isabella Muylaert
Ka-Wei Tang
Per Elias
Published in Journal of Biological Chemistry
Volume 286
Issue 18
ISSN 0021-9258
Publication year 2011
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Language en
Keywords DNA recombination, DNA repair, DNA replication, Herpesvirus, Viral replication, ICP8, UL42, UL5, UL52, UL9
Subject categories Immunology in the medical area, Microbiology in the medical area


Replication of Herpes simplex virus takes place in the cell nucleus and is carried out by a replisome composed of viral proteins: the UL30/42 DNA polymerase, the UL5,8,52 helicase-primase and the UL29 single-strand DNA binding protein ICP8. The replisome is loaded on origins of replication by an initiator protein OBP/UL9. Virus replication is intimately coupled to recombination and repair, often performed by cellular proteins. Here we review significant new developments: the three-dimensional structures for the DNA polymerase, the polymerase accessory factor and the single-strand DNA binding protein, the reconstitution of a functional replisome in vitro, the elucidation of the mechanism for activation of origins of DNA replication, the identification of cellular proteins actively involved in or responding to viral DNA replication and, finally, the elucidation of requirements for formation of replication foci in the nucleus and effects on protein localization.

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