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Composition and functional role of the mucus layers in the intestine.

Review article
Authors Malin E V Johansson
Daniel Ambort
Thaher Pelaseyed
André Schütte
Jenny K Gustafsson
Anna Ermund
Durai B Subramani
Jessica Holmén Larsson
Kristina A Thomsson
Joakim H. Bergström
Sjoerd van der Post
Ana María Rodríguez-Piñeiro
Henrik Sjövall
Malin Bäckström
Gunnar C. Hansson
Published in Cellular and Molecular Life Sciences
Volume 68
Pages 3635-3641
ISSN 1420-682X
Publication year 2011
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 3635-3641
Language en
Links https://doi.org/10.1007/s00018-011-...
Subject categories Cell and Molecular Biology

Abstract

In discussions on intestinal protection, the protective capacity of mucus has not been very much considered. The progress in the last years in understanding the molecular nature of mucins, the main building blocks of mucus, has, however, changed this. The intestinal enterocytes have their apical surfaces covered by transmembrane mucins and the whole intestinal surface is further covered by mucus, built around the gel-forming mucin MUC2. The mucus of the small intestine has only one layer, whereas the large intestine has a two-layered mucus where the inner, attached layer has a protective function for the intestine, as it is impermeable to the luminal bacteria.

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