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Auditory Cortex Responses to Clicks and Sensory Modulation Difficulties in Children with Autism Spectrum Disorders (ASD)

Journal article
Authors Elena V Orekhova
M. M. Tsetlin
A. V. Butorina
S. I. Novikova
V. V. Gratchev
P. A. Sokolov
Mikael Elam
T. A. Stroganova
Published in Plos One
Volume 7
Issue 6
ISSN 1932-6203
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Language en
Links dx.doi.org/10.1371/journal.pone.003...
Keywords superior temporal gyrus, reduced thalamic volume, evoked, magnetic-fields, surface-based analysis, young-children, functional, neuroanatomy, infantile-autism, brain size, meg, abnormalities, nitz em, 1983, international journal of neuroscience, v19, p85
Subject categories Neurology, Psychiatry

Abstract

Auditory sensory modulation difficulties are common in autism spectrum disorders (ASD) and may stem from a faulty arousal system that compromises the ability to regulate an optimal response. To study neurophysiological correlates of the sensory modulation difficulties, we recorded magnetic field responses to clicks in 14 ASD and 15 typically developing (TD) children. We further analyzed the P100m, which is the most prominent component of the auditory magnetic field response in children and may reflect preattentive arousal processes. The P100m was rightward lateralized in the TD, but not in the ASD children, who showed a tendency toward P100m reduction in the right hemisphere (RH). The atypical P100m lateralization in the ASD subjects was associated with greater severity of sensory abnormalities assessed by Short Sensory Profile, as well as with auditory hypersensitivity during the first two years of life. The absence of right-hemispheric predominance of the P100m and a tendency for its right-hemispheric reduction in the ASD children suggests disturbance of the RH ascending reticular brainstem pathways and/or their thalamic and cortical projections, which in turn may contribute to abnormal arousal and attention. The correlation of sensory abnormalities with atypical, more leftward, P100m lateralization suggests that reduced preattentive processing in the right hemisphere and/or its shift to the left hemisphere may contribute to abnormal sensory behavior in ASD.

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