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The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis/painful bladder syndrome.

Review article
Authors R Vesela
Patrik Aronsson
Michael Andersson
V Wsol
Gunnar Tobin
Published in Journal of physiology and pharmacology
Volume 63
Issue 3
Pages 209-216
ISSN 1899-1505
Publication year 2012
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 209-216
Language en
Keywords interstitial cystitis, urinary bladder, pituitary adenylate, cyclase-activating peptide, substance P, vasoactive intestinal polypeptide
Subject categories Pharmacology


Regulation of bladder function involves both divisions of the autonomic nervous system. However, in addition to the classical autonomic transmitters, noradrenaline and acetylcholine, other autonomic transmitters and other signalling components play important roles in physiology and pathophysiology of the lower urinary tract. Several substances of neuronal non-adrenergic, non-cholinergic (NANC) systems have already proven to considerably influence functional responses in the inflamed urinary bladder. Interstitial cystitis (IC) or painful bladder syndrome (PBS) is a chronic inflammatory bladder disease, characterized by urinary frequency, urgency and pelvic pain. IC/PBS is difficult to diagnose, especially because the etiology of the condition is largely unknown. Despite the unclear nature of the cause and manifestation of IC/PBS, it has been shown that the disease involves a significant NANC component. Here, we review the possible roles of ATP, adenosine, nitric oxide, vasoactive intestinal polypeptide, substance P, and pituitary adenylate cyclase-activating peptide in the contribution to IC/PBS development and manifestation of IC/PBS symptoms.

Page Manager: Webmaster|Last update: 9/11/2012

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