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The heterogeneity of asthma phenotypes in children and young adults.

Journal article
Authors Bill Hesselmar
Anna-Carin Enelund
Bo Eriksson
Leonid Padyukov
Lars Å Hanson
Nils Åberg
Published in Journal of allergy
Volume 2012
Pages 163089
ISSN 1687-9791
Publication year 2012
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences, Department of Pediatrics
Institute of Clinical Sciences
Pages 163089
Language en
Links dx.doi.org/10.1155/2012/163089
Subject categories Pediatrics

Abstract

Objective. Genetic heterogeneity and risk factor distribution was analyzed in two previously proposed asthma phenotypes. Method. A sample of 412 subjects was investigated at 7-8, 12-13, and 21-22 years of age with questionnaires, skin prick tests, and genetic analysis of IL-4 receptor (IL4R) single-nucleotide polymorphisms. The sample was subdivided in one group with no asthma, and two groups with asthma separated by age of onset of symptoms, namely, early onset asthma (EOA) and late onset asthma (LOA). Risk factors and IL4R markers were analyzed in respect to asthma phenotypes. Results. EOA and LOA groups were both associated with atopy and a maternal history of asthma. Female gender was more common in LOA, whereas childhood eczema, frequent colds in infancy, and a paternal history of asthma were more common in EOA. The AA genotype of rs2057768 and the GG genotype of rs1805010 were more common in LOA, whereas the GG genotype of rs2107356 was less common in EOA. Conclusion. Our data suggest that early and late onset asthma may be of different endotypes and genotypes.

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