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Long-term mortality and causes of death in isolated GHD, ISS, and SGA patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE study.

Journal article
Authors Lars Sävendahl
Marc Maes
Kerstin Albertsson-Wikland
Birgit Borgström
Jean-Claude Carel
Séverine Henrard
Niko Speybroeck
Muriel Thomas
Gladys Zandwijken
Anita Hokken-Koelega
Published in The Journal of clinical endocrinology and metabolism
Volume 97
Issue 2
Pages E213-7
ISSN 1945-7197
Publication year 2012
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages E213-7
Language en
Keywords Adolescent, Adult, Adverse Drug Reaction Reporting Systems, statistics & numerical data, Belgium, epidemiology, Cause of Death, trends, Child, Cohort Studies, Dwarfism, Pituitary, drug therapy, epidemiology, mortality, Europe, epidemiology, Female, Growth Disorders, drug therapy, epidemiology, mortality, Human Growth Hormone, adverse effects, deficiency, therapeutic use, Humans, Infant, Newborn, Infant, Small for Gestational Age, growth & development, Male, Netherlands, epidemiology, Pilot Projects, Recombinant Proteins, adverse effects, therapeutic use, Survival Rate, trends, Sweden, epidemiology, Time Factors, Young Adult
Subject categories Pediatrics


The long-term mortality in adults treated with recombinant GH during childhood has been poorly investigated. Recently released data from the French part of the European Union Safety and Appropriateness of GH treatments in Europe (EU SAGhE) study have raised concerns on the long-term safety of GH treatment.

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