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Impact of IL28B-related single nucleotide polymorphisms on liver histopathology in chronic hepatitis C genotype 2 and 3.

Journal article
Authors Karolina Rembeck
Åsa Alsiö
Peer Brehm Christensen
Martti Färkkilä
Nina Langeland
Mads Rauning Buhl
Court Pedersen
Kristine Mørch
Johan Westin
Magnus Lindh
Kristoffer Hellstrand
Gunnar Norkrans
Martin Lagging
Published in PloS one
Volume 7
Issue 1
Pages e29370
ISSN 1932-6203
Publication year 2012
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages e29370
Language en
Links dx.doi.org/10.1371/journal.pone.002...
Keywords Adult, Alanine Transaminase, blood, Aspartate Aminotransferases, blood, Fatty Liver, complications, genetics, virology, Female, Genetic Predisposition to Disease, Hepacivirus, genetics, Hepatitis C, Chronic, blood, complications, genetics, virology, Humans, Inflammation, complications, pathology, Interleukins, genetics, Liver, pathology, virology, Male, Middle Aged, Polymorphism, Single Nucleotide, genetics, RNA, Viral, genetics, Viral Load, genetics
Subject categories Microbiology in the medical area, Clinical virology, Infectious Medicine

Abstract

Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of HCV infection as well as outcome following peginterferon and ribavirin therapy among HCV genotype 1 infected patients. The present study aimed to evaluate the impact of IL28B SNP variability on liver histology in the context of a phase III treatment trial (NORDynamIC) for treatment-naïve patients with chronic HCV genotype 2 or 3 infection, where pretreatment liver biopsies were mandatory.

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